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Identifying behavioral links to neural dynamics of multifiber photometry recordings in a mouse social behavior network

Chen, Y., Chien, J., Dai, B., Lin, D., Chen ZS. 

Journal of Neural Engineering, 2024 [Link[BioRxiv version

Monitoring norepinephrine release in vivo using next-generation GRABNE sensors

Feng, J., Dong, H., Lischinsky, J.E., Zhou J., Deng F., Zhuang C., Miao X., Wang H., Li G., Cai R., Xie H., Cui G., Lin, D., Li, Y.
Neuron. 2024 Mar 27. [link]

Brain-wide multi-fiber recording of neuronal activity in freely moving mice

Dai B., Guo Z., Lin, D.
STAR Protocols. 2024 Mar 15. [link]

A dedicated hypothalamic oxytocin circuit controls aversive social learning

Osakada, T., Yan, R., Jiang Y., Wei, D., Tabuchi, R., Dai B., Wang, X., Zhao, G., Wang, C.X., Liu, J.J., Tsien, R.W., Mar, A.C., Lin, D.
​Nature. 2024 Jan 24. [link][BioRxiv version
][Raw data]


A toolkit of highly selective and sensitive genetically encoded neuropeptide sensors

Wang H., Qian T., Zhao Y., Zhuo Y., Wu C., Osakada T., Chen P., Chen Z., Ren H., Yan Y., Geng L., Fu S., Mei L., Li G., Wu L., Jiang Y., Qian W., Zhang L., Peng W., Xu M., Hu J., Jiang M., Chen L., Tang C., Zhu Y., Lin D., Zhou J.N.,  Li Y.

Science. 2023 Nov 17. [link][BioRxiv version]

Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors

Lischinsky, J., Yin, L., Shi, C., Prakash, N., Burke, J., Shekaran, G., Grba, M., Corbin, J.G., Lin, D.

Nature Neuroscience2023 Nov 09. [link][BioRxiv version][Raw data]

Hypothalamic control of innate social behaviors (Review)

Mei, L., Osakada,T., Lin, D.

Science2023 Oct 26. [link

Neural dynamics in the limbic system during male social behaviors

Guo, Z., Yin, L., Diaz, V., Dai,B., Osakada,T., Lischinsky, J.E., Chien, J., Yamaguchi, T., Urtecho, A., Tong, X., Chen, Z.S., Lin, D.

Neuron2023 Aug 15. [link] [BioRxiv version][Raw data]

Antagonistic circuits mediating infanticide and maternal care in female mice

Mei, L., Yan, R., Yin, L., Sullivan, R.M., Lin, D.

Nature. 2023 Jun 07. [link[BioRxiv version][Raw data]

A hypothalamic pathway that suppresses aggression toward superior opponents

Wei, D., Osakada, T., Guo, Z., Yamaguchi, T., Varshneya, A., Yan, R., Jiang, Y., Lin, D.

Nature Neuroscience2023 Apr 10. [link][Raw data]

Neural control of female sexual behaviors (Review)

Yin, L., Lin, D.

Hormones and Behavior. 2023 Mar 04. [link]

A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments

Qian, T., Wang, H., Wang, P., Geng, L., Mei, L., Osakada, T., Wang, L., Tang, Y., Kania, A., Grinevich, V., Stoop, R., Lin, D., Luo, M., Li, Y.

Nature Biotechnology. 2023 Jan 02. [PDF] [BioRxiv version]


Responses and functions of dopamine in nucleus accumbens core during social behaviors

Dai, B., Sun, F., Tong. X., Ding, Y., Kuang, A., Osakada, T., Li, Y., Lin, D.
Cell Reports. 2022 Aug 23. [PDF] 
[Supplement[BioRxiv version]

VMHvllCckar cells dynamically control female sexual behaviors over the reproductive cycle

Yin, L., Hashikawa, K., Hashikawa, Y., Osakada, T., Lischinsky, J.E., Diaz, V., Lin, D.
Neuron. 20
22 Jul 26. [PDF][Supplement

Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators (Review)

Wu, Z., Lin, D., Li, Y.
Nature Reviews Neuroscience. 2022 Mar 31. [


Oxytocin neurons enable social transmission of maternal behaviour

Carcea, I., Caraballo, N.L., Marlin, B.J., Ooyama, R., Riceberg, J.S., Mendoza Navarro, J.M., Opendak, M., Diaz, V.E., Schuster, L., Alvarado Torres, M.I., Lethin, H., Ramos, D., Minder, J., Mendoza, S.L., Bair-Marshall, C.J., Samadjopoulos, G.H., Hidema, S., Falkner, A., Lin, D., Mar, A., Wadghiri, Y.Z., Nishimori, K., Kikusui, T., Mogi, K., Sullivan, R.M., Froemke, R.C.
​Nature. 2021 Aug 11. [
PDF] [BioRxiv version]

Neural circuits of social behaviors: innate yet flexible (Review)

Wei, D., Talwar, V., Lin, D.

Neuron. 2021 Mar 10. [PDF]


Next-generation GRAB sensors for monitoring dopaminergic activity in vivo

Sun, F., Zhou, J., Dai, B., Qian, T., Zeng, J., Li, X., Zhuo, Y., Zhang, Y., Wang, Y., Qian, C., Tan, K., Feng, J., Dong, H., Lin, D., Cui, G., Li, Y.

Nature Methods. 2020 Oct 21. [PDF] [BioRxiv version]

Neural mechanisms of aggression across species (Review)

Lischinsky, J.E., Lin, D.

Nature Neuroscience. 2020 Oct 12. [PDF]

Posterior amygdala regulates sexual and aggressive behaviors in male mice

Yamaguchi, T., Wei, D., Song, S.C., Lim, B., Tritsch, N.X., Lin, D.

Nature Neuroscience. 2020 July 27. [PDF

Simple Behavioral Analysis (SimBA) – an open source toolkit for computer classification of complex social behaviors in experimental animals

Nilsson, S., Goodwin, N.L., Choong, J.J., Hwang, S., Wright, H. R., Norville, Z.C., Tong, X., Lin, D., Bentzley, B.S., Eshel, N., McLaughlin, R. J., Golden, S.A.

bioRxiv. 2020 Apr 21. [PDF]

Hierarchical Representations of Aggression in a Hypothalamic-Midbrain Circuit

Falkner, A., Wei, D., Song, A., Watsek, L. W., Chen, I., Chen, P., Feng, J., Lin, D.

Neuron. 2020 Mar 11. [PDF[Supplement[BioRxiv version]

Neural circuits for coping with social defeat (Review)

Diaz, V., Lin, D.

Current Opinion in Neurobiology. 2020 Feb. [PDF]


A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine

Feng, J., Zhang, C., Lischinsky, J., Jing, M., Zhou, J., Wang, H., Zhang, Y., Dong, A., Wu, Z., Wu, H., Chen, W., Zhang, P., Zou, J., Hires, A., Zhu, J.J., Cui, G., Lin, D., Du, J., Li, Y.

Neuron. 2019 Mar 25. [PDF] [Supplement[BioRxiv version]

Rapid, biphasic CRF neuronal responses encode positive and negative valence

Kim, J., Lee, S., Fang, Y., Shin, A., Park, S., Hashikawa, K., Bhat, S., Kim, D., Sohn, J.W., Lin, D., Suh, G.S.B.

Nature Neuroscience. 2019 Mar 4. [PDF] [Supplement [BioRxiv version]

Hypothalamic Control of Conspecific Self-Defense

Wang, L., Talwar, V., Osakada, T., Kuang, A., Guo, Z., Yamaguchi, T., Lin, D.

Cell Reports. 2019 Feb 12. [PDF] [Supplement]




The Neural Mechanisms of Sexually Dimorphic Aggressive Behaviors (Review)

Hashikawa, K., Hashikawa, Y., Lischinsky, J.,  Lin, D.

Trends in Genetics. 2018 August 30. [PDF]


A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice

Sun, F., Zeng, J., Jing, M., Zhou, J., Feng, J., Owen, S. F., Luo, Y., Li, F., Wang, H., Yamaguchi, T., Yong, Z., Gao, Y., Peng, W., Wang, L., Zhang, S.,  Du, J., Lin, D., Xu, M., Kreitzer, A. C., Cui, G., Li, Y.

Cell. 2018 July 12. [PDF] [Supplement] [BioRxiv version]


Functions of medial hypothalamic and mesolimbic dopamine circuitries in aggression (Review)

Yamaguchi, T., Lin, D. 

Current Opinion In Behavioral Sciences.  2018 July 3.  [PDF


A Hypothalamic Midbrain Pathway Essential for Driving Maternal Behaviors

Fang, Y., Yamaguchi, T., Song, S.C., Tritsch, N.X.,  Lin, D. 

Neuron.  2018 Apr 4.  [PDF] [Supplement]


Ventromedial Hypothalamus and the Generation of Aggression (Review)

Hashikawa, Y., Hashikawa, K., Falkner, A.L., Lin, D. 

Frontiers in Systems Neuroscience.  2017 Dec 20.  [PDF


Esr1+ cells in the ventromedial hypothalamus control female aggression  

Hashikawa, K., Hashikawa, Y., Tremblay, R., Zhang, J., Feng, J.E., Sabol, A., Piper, W.T., Lee, H., Rudy, B., Lin, D. 

Nature Neuroscience.  2017 Sep 18.  [PDF] [Supplement]



Hypothalamic control of male aggression-seeking behavior

Falkner, A.L., Grosenick, L., Davidson, T.J., Deisseroth, K., Lin, D. 

Nature Neuroscience.  2016 Apr;19(4):596-604.  [PDF] [Supplement]


Effective modulation of male aggression through lateral septum to medial hypothalamus projection

Wong, L.C., Wang, L., D’amour, J.A., Yumita, T., Chen, G., Yamaguchi, T., Chang, B., Bernstein, H., You, X., Feng, J.E., Froemke, R.C., Lin, D.

Current Biology.  2016 Mar 7;26(5):593-604.  [PDF] [Supplement]


The neural circuits of mating and fighting in male mice (Review)

Hashikawa, K., Hashikawa, Y., Falkner, A.L., Lin, D. 

Current Opinion In Neurobiology. 2016 Jun; 38:27-37.  [PDF



Collateral Pathways from the Ventromedial Hypothalamus Mediate Defensive Behaviors

Wang, L., Chen, I.Z., Lin, D. 

Neuron. 2015 Mar 18;85(6):1344-58.  [PDF] [Supplement]


Recent advances in understanding the role of the hypothalamic circuit during aggression (Review)

Falkner, A.L., Lin, D. 

Frontiers In Systems Neuroscience. 2014 Sep 25;8:168.  [PDF]


Decoding ventromedial hypothalamic neural activity during male mouse aggression

Falkner, A.L., Dollar, P., Perona, P., Anderson, D.J., Lin, D. 

Journal of Neuroscience. 2014 Apr 23;34(17):5971-84.  [PDF]


Functional identification of an aggression locus in the mouse hypothalamus

Lin, D., Boyle, M.P., Dollar, P., Lee, H., Perona, P., Lein, E.S., Anderson, D.J. 

Nature. 2011 Feb 10;470(7333):221-6. [PDF]


Representation of natural stimuli in the mouse main olfactory bulb

Lin, D., Shea, S.D., Katz, L.C. 

Neuron. 2006 Jun 15;50(6):937-49. [PDF] [Supplement]


Encoding social signals in the mouse main olfactory bulb

Lin, D., Zhang, S.Z., Block, E., Katz, L.C. 

Nature. 2005 Mar 24;434(7032):470-7. [PDF]


Molecular determinants of synapsin targeting to presynaptic terminals

Gitler, D., Xu, Y., Kao, H.T., Lin, D., Lim, S., Feng, J., Greengard, P., Augustine, G.J.

Journal of Neuroscience. 2004 Apr 7;24(14):3711-20. [PDF]


Alpha-2 macroglobulin I1000 V polymorphism in Chinese sporadic Alzheimer's disease and Parkinson's disease

Tang, G., Zhang, M., Xie, H., Jiang, S., Wang, Z., Xu, L., Hao, Y., Lin, D., Lan, H., Wang, Y,, Chen, L., Ren, D. (2002)

Neuroscience Letter. 2002 Aug 9;328(2):195-7. 


Genetic study of apolipoprotein E gene, alpha-1 antichymotrypsin gene in sporadic Parkinson disease

Tang, G., Xie, H., Xu, L., Hao, Y., Lin, D., Ren, D.

Am J Med Genet. 2002 May 8;114(4):446-9.

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